The effects of vitamin D deficiency on atrial fibrillation

Clin Appl Thromb Hemost. 2014 Jan;20(1):98-103. doi: 10.1177/1076029612453762. Epub 2012 Jul 23.


Background: Vitamin D deficiency is associated with cardiovascular disease such as coronary artery disease, heart failure, and hypertension. Vitamin D deficiency activates the renin-angiotensin-aldosterone system, which affects the cardiovascular system. For this reason, it could be suggested that there is a relationship between vitamin D deficiency and atrial fibrillation (AF). In our study, we compared 25-hydroxyvitamin D (25-OHD) levels between nonvalvular AF, valvular AF, and control groups in sinus rhythm.

Method: A total of 102 patients with nonvalvular chronic AF without any other cardiovascular disease (mean age 62.51 ± 5.88; group I) and 96 patients with AF, which is associated with mitral valve disease (mean age 61.51 ± 5; group II) were included in our study. Of all, 100 age-matched healthy people with sinus rhythm were accepted as control groups (mean age 61.35 ± 5.44). Routine biochemical parameters, 25-OHD and parathormone levels were performed.

Results: Baseline characteristics of the study groups were comparable. Group I patients had a lower vitamin D level than group II and the control group (6.51 ± 4.89, 9.24 ± 7.39, and 11.18 ± 6.98 ng/mL, P < .001, respectively). In groups I and II, the patients' left atrium diameter and systolic pulmonary artery pressure are higher than the control group.

Conclusion: As a result, our study revealed a relationship between vitamin D deficiency and nonvalvular AF.

Keywords: arrhythmia; atrial fibrillation; renin–angiotensin–aldosterone system; vitamin D.

MeSH terms

  • Aged
  • Atrial Fibrillation / blood*
  • Atrial Fibrillation / diagnostic imaging
  • Case-Control Studies
  • Echocardiography
  • Female
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Renin-Angiotensin System
  • Vitamin D / analogs & derivatives
  • Vitamin D / blood
  • Vitamin D Deficiency / blood*
  • Vitamin D Deficiency / diagnostic imaging


  • Vitamin D
  • 25-hydroxyvitamin D