Helios expression in FoxP3(+) T regulatory cells

Expert Opin Biol Ther. 2012 Nov;12(11):1423-5. doi: 10.1517/14712598.2012.711310. Epub 2012 Jul 25.


Recent work debates the suitability of Helios, an Ikarios family transcription factor, as a marker of thymic-derived natural T regulatory cells. However, Helios expression could be of particular importance in cancer. We and others reported that the majority of peripheral and tumour-infiltrating FoxP3(+) Tregs expresses Helios. Additionally, recent observations indicate that FoxP3(+)Helios(+) Tregs possess more suppressive characteristics, as compared to FoxP3(+)Helios(-) Tregs.

Publication types

  • Editorial

MeSH terms

  • Animals
  • CD8-Positive T-Lymphocytes / metabolism
  • Forkhead Transcription Factors / biosynthesis*
  • Gene Expression Regulation
  • Humans
  • Ikaros Transcription Factor / biosynthesis*
  • T-Lymphocytes, Regulatory / metabolism*
  • Transcription Factors / metabolism


  • FOXP3 protein, human
  • Forkhead Transcription Factors
  • IKZF2 protein, human
  • Transcription Factors
  • Ikaros Transcription Factor