Trough concentrations of vancomycin: adult therapeutic targets are not appropriate for children

Pediatr Infect Dis J. 2012 Dec;31(12):1269-71. doi: 10.1097/INF.0b013e31826a3eaf.

Abstract

Despite the need for effective vancomycin therapy, there are few data guiding vancomycin monitoring in children. We reviewed retrospectively vancomycin use in children 1 month to 12 years of age. Initial and adjusted target trough vancomycin concentrations in serum were infrequently achieved regardless of the dosing schedule. Currently recommended trough concentrations need to be re-examined with a more detailed pharmacokinetic study in children.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / administration & dosage*
  • Anti-Bacterial Agents / pharmacokinetics*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Male
  • Serum / chemistry
  • Vancomycin / administration & dosage*
  • Vancomycin / pharmacokinetics*

Substances

  • Anti-Bacterial Agents
  • Vancomycin