The hypercoagulable state in patients with diabetes mellitus, glomerular diseases and pregnancy induced hypertension was studied by using new methods. The research items included platelet function, coagulation, anti-coagulation system, fibrinolysis and TEG examination. The results showed that there was a hypercoagulable state in patients with diabetes mellitus, pregnancy induced hypertension and glomerular diseases, especially in those with uremia and nephrotic syndrome.