Many aspects of the embryo culture environment have been shown to affect embryo development and the subsequent outcomes of human ART. It is now becoming increasingly evident that embryo and later development can be affected by events and conditions that occur before, perhaps long before, the oocytes and sperm are collected and brought together in the ART laboratory. These include diet and metabolic disorders, general health and disease, physical and psychological stress, exposure to environmental estrogens and other toxins, pharmaceuticals, alcohol, smoking, and drug abuse. This paper discusses the known and potential effects of season of the year (or temperature) and environmental air pollution on the outcomes of human ART. It may be useful to advise ART patients to avoid high environmental temperature and air pollution. In addition, it is important for clinical embryologists to recognize that adverse outcomes may result from such exposures, and to incorporate this into the analysis of clinic data for the purposes of quality management.