Effects of manganese from a commercial multi-trace element supplement in a population sample of Canadian patients on long-term parenteral nutrition

JPEN J Parenter Enteral Nutr. 2013 Jul;37(4):538-43. doi: 10.1177/0148607112454543. Epub 2012 Jul 24.


Background: Long-term parenteral nutrition (PN) can be associated with micronutrient deficiency or toxicity depending on supplementation. Recently, hypermanganesemia and potential neurological toxicity were reported. The aim of this study was to assess the effect of manganese supplementation in a sample of patients on long-term PN receiving manganese (Mn) as part of a multi-trace element (TE) supplement.

Methods: A convenience sample of 16 patients underwent clinical and blood biochemical measurements as well as magnetic resonance imaging (MRI) of the brain. Descriptive statistics were performed.

Results: The mean daily Mn supplementation was 7.28 ± 0.97 µmol/d (400 ± 53 µg/d), which was within the American Medical Association Nutrition Advisory Group guidelines of 2.73-14.56 μmol/d (150-800 µg/d) but exceeded the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) 2002 recommendations of 1.09-1.82 µmol/d (60-100 µg/d). The mean whole blood Mn level was 1.38 ± 0.29 times the upper limit of normal (ULN), and 8 of 14 patients with blood measurements had Mn levels above ULN. On MRI, 81% of patients had high signals on T1-weighted images assumed to be Mn deposits in their basal ganglia. Two patients with positive MRI (15%) had a clinical diagnosis of Parkinson disease. Multiple neuropsychiatric complaints were reported, including depression (66%), lack of concentration (42%), memory disturbances (17%), and gait instability (8%).

Conclusion: These results suggest that Mn status is elevated in these patients. Manganese supplementation should be used with caution in patients receiving long-term PN, and attention should be paid to the Mn content of multi-TE supplements.

Keywords: Parkinsonian-like; basal ganglia deposit; home parenteral nutrition; hypermanganesemia; manganese toxicity; neuropsychiatric.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Attention / drug effects
  • Brain / drug effects*
  • Brain / pathology
  • Canada / epidemiology
  • Cognition Disorders / blood
  • Cognition Disorders / chemically induced
  • Cognition Disorders / epidemiology
  • Depression / blood
  • Depression / chemically induced
  • Depression / epidemiology
  • Dietary Supplements / adverse effects*
  • Female
  • Gait / drug effects
  • Gait Disorders, Neurologic / blood
  • Gait Disorders, Neurologic / chemically induced
  • Gait Disorders, Neurologic / epidemiology
  • Humans
  • Male
  • Manganese / adverse effects*
  • Manganese / blood
  • Memory Disorders / blood
  • Memory Disorders / chemically induced
  • Memory Disorders / epidemiology
  • Middle Aged
  • Parenteral Nutrition*
  • Parkinson Disease / blood
  • Parkinson Disease / epidemiology
  • Parkinson Disease / etiology
  • Trace Elements / adverse effects*
  • Trace Elements / blood
  • Young Adult


  • Trace Elements
  • Manganese