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. 2012 Sep 3;13(13):1953-8.
doi: 10.1002/cbic.201200291. Epub 2012 Jul 24.

Chemical Proteomics Reveals Heat Shock Protein 60 to Be the Main Cellular Target of the Marine Bioactive Sesterterpene Suvanine

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Chemical Proteomics Reveals Heat Shock Protein 60 to Be the Main Cellular Target of the Marine Bioactive Sesterterpene Suvanine

Chiara Cassiano et al. Chembiochem. .

Abstract

Marine bioactive compounds are potential drug leads because of their diverse pharmacological effects against human diseases. The identification of their cellular targets is crucial for a rational approach to their application in medicinal chemistry. Thus, we have analyzed the cell interactome of suvanine, a sulfated tricyclic terpenoid of marine origin endowed with an interesting anti-inflammatory activity, by application of a chemical proteomic approach. Heat Shock Protein 60, a chaperone involved in the inflammatory response, is the main cellular target of suvanine, which is also able to interfere with protein chaperone activity, giving evidence for its anti-inflammatory properties.

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