Folding RNA/DNA hybrid duplexes

Bioinformatics. 2012 Oct 1;28(19):2530-1. doi: 10.1093/bioinformatics/bts466. Epub 2012 Jul 24.


Motivation: While there are numerous programs that can predict RNA or DNA secondary structures, a program that predicts RNA/DNA hetero-dimers is still missing. The lack of easy to use tools for predicting their structure may be in part responsible for the small number of reports of biologically relevant RNA/DNA hetero-dimers.

Results: We present here an extension to the widely used ViennaRNA Package (Lorenz et al., 2011) for the prediction of the structure of RNA/DNA hetero-dimers.



Supplementary information: Supplementary data are available at Bioinformatics online.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Computational Biology / methods
  • DNA / chemistry*
  • Dimerization
  • RNA / chemistry*
  • RNA Folding*
  • Software*


  • RNA
  • DNA