Softer zwitterionic nanogels for longer circulation and lower splenic accumulation

ACS Nano. 2012 Aug 28;6(8):6681-6. doi: 10.1021/nn301159a. Epub 2012 Aug 1.


Zwitterionic nanogels of varying stiffness were prepared by tuning their cross-linking densities and reactant contents. In vivo studies of these nanogels show that softer nanogels pass through physiological barriers, especially the splenic filtration, more easily than their stiffer counterparts, consequently leading to longer circulation half-life and lower splenic accumulation. Results from this work emphasize the role of stiffness in designing long-circulating nanoparticles.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Biocompatible Materials / chemistry*
  • Blood Chemical Analysis*
  • Hardness
  • Hydrogels / chemical synthesis*
  • Materials Testing
  • Molecular Conformation
  • Nanoparticles / chemistry*
  • Nanoparticles / ultrastructure*
  • Particle Size
  • Rats
  • Spleen / chemistry*
  • Static Electricity
  • Surface Properties


  • Biocompatible Materials
  • Hydrogels