Accurate long-term prediction of height during the first four years of growth hormone treatment in prepubertal children with growth hormone deficiency or Turner Syndrome

Horm Res Paediatr. 2012;78(1):8-17. doi: 10.1159/000339468. Epub 2012 Jul 24.


Background/aims: The study aim was to develop and validate models for long-term prediction of growth in prepubertal children with idiopathic growth hormone deficiency (GHD) or Turner syndrome (TS) for optimal, cost-effective growth hormone (GH) therapy.

Methods: Height was predicted by sequential application of annual prediction algorithms for height velocity in cohorts of GHD (n = 664) and TS (n = 607) as documented within KIGS (Pfizer International Growth Database). As height prediction models also require an estimate of weight, new algorithms for weight increase during the first to fourth prepubertal years on GH were developed.

Results: When height was predicted from the start of GH treatment, the predicted and observed mean (SD) gain over 4 years was 30.4 (3.4) cm and 30.1 (4.9) cm, respectively, in GHD patients, and 27.2 (2.2) cm and 26.6 (3.5) cm, respectively, in TS patients. For all 4 years, gains of weight SD scores (SDS) were accurately described as a function of weight SDS and observed gain in height SDS (R(2) > 0.89).

Conclusion: In GHD and TS patients treated with GH, an accurate prepubertal long-term prediction of height development in groups is possible. Based on this, an optimal individual height outcome could be simulated.

Publication types

  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Age Factors
  • Body Height / physiology*
  • Child
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Forecasting* / methods
  • Growth Disorders / diagnosis*
  • Growth Disorders / drug therapy*
  • Growth Disorders / physiopathology
  • Human Growth Hormone / deficiency
  • Human Growth Hormone / pharmacology
  • Human Growth Hormone / therapeutic use*
  • Humans
  • Male
  • Prognosis
  • Puberty / drug effects
  • Puberty / physiology
  • Reproducibility of Results
  • Time Factors
  • Turner Syndrome / diagnosis*
  • Turner Syndrome / drug therapy*
  • Turner Syndrome / physiopathology


  • Human Growth Hormone