[Ladasten versus placebo effect self-evaluated by neurasthenia patients with different EEG alpha rhythm types]

Eksp Klin Farmakol. 2012;75(5):7-13.
[Article in Russian]


The study was focused on the clinico-pharmacological analysis of differences between subjective and objective assessment of the effects of antiasthenic drug ladasten and placebo effects in patients with neurasthenia with different individual patterns manifested in their EEG alpha rhythms and MMPI findings. It is established that, in patients with neurasthenia characterized by reduced EEG alpha activity combined with emotional lability and inertness, the therapeutic action and effectiveness of ladasten and placebo was more robust (the subjective estimation was higher) than in patients with prominent alpha rhythm and sthenic personal traits. The self-assessment of the effect of single test doses of ladasten and placebo was independent of the individual differences of EEG alpha rhythm organization and personal traits with respect to tolerability, wish to continue the treatment, activating and calming effects. In long-term treatment, higher subjective estimations of the ladasten and placebo effect appeared in patients with reduced EEG alpha rhythm, and the difference corresponded to objective indices of the psychotropic action and effectiveness of the drug.

Publication types

  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Adamantane / analogs & derivatives*
  • Adamantane / therapeutic use
  • Adolescent
  • Adult
  • Alpha Rhythm / drug effects*
  • Diagnostic Self Evaluation
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neurasthenia / drug therapy*
  • Neurasthenia / physiopathology
  • Placebo Effect
  • Psychotropic Drugs / pharmacology
  • Psychotropic Drugs / therapeutic use*


  • N-(2-adamantyl)-N-p-bromophenylamine
  • Psychotropic Drugs
  • Adamantane