Hyperthermia-induced DNA repair deficiency suggests novel therapeutic anti-cancer strategies

Int J Hyperthermia. 2012;28(6):509-17. doi: 10.3109/02656736.2012.695427. Epub 2012 Jul 26.


Local hyperthermia is an effective treatment modality to augment radio- and chemotherapy-based anti-cancer treatments. Although the effect of hyperthermia is pleotropic, recent experiments revealed that homologous recombination, a pathway of DNA repair, is directly inhibited by hyperthermia. The hyperthermia-induced DNA repair deficiency is enhanced by inhibitors of the cellular heat-shock response. Taken together, these results provide the rationale for the development of novel anti-cancer therapies that combine hyperthermia-induced homologous recombination deficiency with the systemic administration of drugs that specifically affect the viability of homologous recombination deficient cells and/or inhibit the heat-shock response, to locally sensitise cancer cells to DNA damaging agents.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • DNA Breaks, Double-Stranded / drug effects
  • DNA Repair*
  • DNA Repair-Deficiency Disorders / etiology*
  • HSP90 Heat-Shock Proteins / antagonists & inhibitors
  • HSP90 Heat-Shock Proteins / physiology
  • Heat-Shock Response
  • Homologous Recombination / physiology
  • Humans
  • Hyperthermia, Induced*
  • Poly (ADP-Ribose) Polymerase-1
  • Poly(ADP-ribose) Polymerase Inhibitors


  • HSP90 Heat-Shock Proteins
  • Poly(ADP-ribose) Polymerase Inhibitors
  • PARP1 protein, human
  • Poly (ADP-Ribose) Polymerase-1