DNA methylation in cognition comes of age

Nat Neurosci. 2012 Jul 26;15(8):1061-2. doi: 10.1038/nn.3169.

Abstract

A study reveals that aged mice have decreased hippocampal expression of the DNA methyltransferase Dnmt3a2; re-expression in aged mice reverses memory deficits, and knockdown in young mice impairs memory formation.

MeSH terms

  • Aging / genetics
  • Aging / metabolism*
  • Aging / psychology
  • Animals
  • Cognition Disorders / enzymology*
  • Cognition Disorders / physiopathology
  • DNA (Cytosine-5-)-Methyltransferases / antagonists & inhibitors
  • DNA (Cytosine-5-)-Methyltransferases / biosynthesis
  • DNA (Cytosine-5-)-Methyltransferases / metabolism*
  • DNA Methylation / physiology*
  • Hippocampus / enzymology*
  • Hippocampus / physiopathology
  • Memory Disorders / enzymology*
  • Memory Disorders / physiopathology
  • Mice

Substances

  • DNA (Cytosine-5-)-Methyltransferases
  • DNA methyltransferase 3A