Long-term outcome of antenatally diagnosed agenesis of corpus callosum and cerebellar malformations

Semin Fetal Neonatal Med. 2012 Oct;17(5):295-300. doi: 10.1016/j.siny.2012.07.001. Epub 2012 Jul 25.


Recent advancements in fetal imaging and antenatal care have enabled identification of numerous anomalies including agenesis of corpus callosum and posterior fossa abnormalities. One of the important determinants of long-term prognosis in these conditions is the presence of central nervous system (CNS) and extra-CNS anomalies. The difficulty in confirming the isolated nature of these conditions antenatally and the lack of clear information regarding long-term prognoses makes it difficult for the clinician to provide accurate information to the parents antenatally. Caring for these families would require input from a multidisciplinary team involving obstetricians, geneticists, neurologists, radiologists and neonatologists.

Publication types

  • Review

MeSH terms

  • Agenesis of Corpus Callosum / diagnostic imaging
  • Agenesis of Corpus Callosum / embryology*
  • Cerebellum / abnormalities*
  • Cerebellum / diagnostic imaging
  • Cerebellum / embryology*
  • Female
  • Fetus
  • Humans
  • Infant
  • Pregnancy
  • Ultrasonography, Prenatal / methods*