Assessment of tamsulosin as a potential male contraceptive in healthy volunteers

Urology. 2012 Sep;80(3):614-7. doi: 10.1016/j.urology.2012.06.003. Epub 2012 Jul 26.


Objective: To investigate the efficacy and safety of tamsulosin, an α(1A)-adrenoceptor antagonist, as a potential male contraceptive.

Methods: Forty healthy male volunteers were equally divided into 2 groups, each of which received placebo and tamsulosin sequentially in a crossover manner. Ejaculatory profile was examined 4 to 6 hours after administration and adverse effects were noted.

Results: Anejaculation occurred in all subjects after taking 0.8-mg of tamsulosin. Total functional sperm count was significantly reduced in subjects after taking 0.4-mg of tamsulosin. Six subjects receiving 0.8-mg of tamsulosin complained of tolerated discomfort, which disappeared 10 hours after administration.

Conclusion: When administered at 0.8 mg, tamsulosin can cause anejaculation with some transient side effects. Our results imply that tamsulosin and related drugs might potentially be used as male contraceptive agents in the future, which needs more studies to verify.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenergic alpha-1 Receptor Antagonists*
  • Adult
  • Contraceptive Agents, Male*
  • Cross-Over Studies
  • Humans
  • Male
  • Single-Blind Method
  • Sulfonamides*
  • Tamsulosin
  • Young Adult


  • Adrenergic alpha-1 Receptor Antagonists
  • Contraceptive Agents, Male
  • Sulfonamides
  • Tamsulosin