The role of induced pluripotent stem cells in research and therapy of primary immunodeficiencies

Curr Opin Immunol. 2012 Oct;24(5):617-24. doi: 10.1016/j.coi.2012.07.001. Epub 2012 Jul 25.


The advent of reprogramming technology has greatly advanced the field of stem cell biology and nurtured our hope to create patient specific renewable stem cell sources. While the number of reports of disease specific induced pluripotent stem cells is continuously rising, the field becomes increasingly more aware that induced pluripotent stem cells are not as similar to embryonic stem cells as initially assumed. Our state of the art understanding of human induced pluripotent stem cells, their capacity, their limitations and their promise as it pertains to the study and treatment of primary immunodeficiencies, is the content of this review.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / immunology*
  • Cell Transplantation / methods
  • Cell Transplantation / trends
  • Disease Models, Animal
  • Humans
  • Immunologic Deficiency Syndromes / pathology*
  • Immunologic Deficiency Syndromes / physiopathology
  • Immunologic Deficiency Syndromes / therapy*
  • Pluripotent Stem Cells / pathology
  • Pluripotent Stem Cells / physiology*
  • Pluripotent Stem Cells / transplantation*
  • Regenerative Medicine / methods*
  • Regenerative Medicine / trends