Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection

Front Med. 2012 Sep;6(3):243-7. doi: 10.1007/s11684-012-0201-y. Epub 2012 Jul 28.


Diabetes has become a major public health problem in China nowadays. There are almost 97 million diabetic patients nationwide. Latent autoimmune diabetes in adults (LADA) is a subtype of autoimmune diabetes. Although it has been reported for about 20 years, the diagnostic criteria of this disease remain controversial. The discussion mainly focused on serum autoantibodies, period of insulin need and age of diagnosis. Besides, β cell function, metabolic parameters, genetic factors and cell immunity may also contribute to the formulation of the criteria. Here, we aim to review and discuss the diagnostic criteria of latent autoimmune diabetes in adults.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Age Factors
  • Autoantibodies / blood
  • Body Mass Index
  • China / epidemiology
  • Diabetes Mellitus, Type 1 / diagnosis*
  • Diabetes Mellitus, Type 1 / epidemiology
  • Diabetes Mellitus, Type 1 / genetics
  • Diagnosis, Differential
  • Humans
  • Risk Factors


  • Autoantibodies