[Magnesium disorder in metabolic bone diseases]

Clin Calcium. 2012 Aug;22(8):1251-6.
[Article in Japanese]


Magnesium is abundantly distributed among the body. The half of the magnesium exists in the bone. In addition, magnesium is the second most abundant intracellular cation in vertebrates and essential for maintaining physiological function of the cells. Epidemiologic studies have demonstrated that magnesium deficiency is a risk factor for osteoporosis. The mechanism of bone fragility caused by magnesium deficiency has been intensely studied using animal models of magnesium deficiency. Magnesium deficiency causes decreased osteoblastic function and increased number of osteoclasts. Magnesium deficiency also accelerates mineralization in bone. These observations suggest that disturbed bone metabolic turnover and mineralization causes bone fragility.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Animals
  • Bone Diseases, Metabolic / etiology
  • Bone Diseases, Metabolic / metabolism*
  • Bone Remodeling
  • Bone and Bones / metabolism*
  • Humans
  • Magnesium / metabolism*
  • Magnesium Deficiency / complications*
  • Osteoblasts / physiology
  • Osteoclasts
  • Osteoporosis / etiology
  • Rats
  • Risk Factors


  • Magnesium