FERM-containing protein FRMD5 is a p120-catenin interacting protein that regulates tumor progression

FEBS Lett. 2012 Sep 21;586(19):3044-50. doi: 10.1016/j.febslet.2012.07.019. Epub 2012 Jul 27.

Abstract

FERM family proteins have been known to play an important role in tumor progression. FERM-domain containing protein 5 (FRMD5), a novel putative cytoskeletal protein, is an unknown function protein. Here, we reported that FRMD5 localized at the cell adherens junction and formed a molecular complex with p120-catenin through its C-terminal region. Functionally, we found that knockdown of endogenous FRMD5 promotes lung cancer cell migration and invasion in vitro as well as tumor growth in vivo, suggesting a tumor suppressive effect. These findings indicated that FRMD5 may play a role in p120-catenin-based cell-cell contact and is involved in the regulation of tumor progression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Catenins / physiology*
  • Cell Line, Tumor
  • Cell Movement
  • Cytoskeletal Proteins / antagonists & inhibitors
  • Cytoskeletal Proteins / chemistry
  • Cytoskeletal Proteins / genetics
  • Cytoskeletal Proteins / physiology*
  • Disease Progression
  • Epithelial-Mesenchymal Transition / physiology
  • Female
  • Gene Knockdown Techniques
  • HCT116 Cells
  • HeLa Cells
  • Humans
  • Lung Neoplasms / genetics
  • Lung Neoplasms / pathology
  • Lung Neoplasms / physiopathology*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Neoplasm Invasiveness
  • Phylogeny
  • Protein Interaction Domains and Motifs
  • RNA, Small Interfering / genetics
  • Tumor Suppressor Proteins / antagonists & inhibitors
  • Tumor Suppressor Proteins / chemistry
  • Tumor Suppressor Proteins / genetics
  • Tumor Suppressor Proteins / physiology*

Substances

  • Catenins
  • Cytoskeletal Proteins
  • RNA, Small Interfering
  • Tumor Suppressor Proteins
  • delta catenin