Complete response in a patient with granulosa cell tumor treated with a combination of leuprolide and tamoxifen

Onkologie. 2012;35(7-8):451-3. doi: 10.1159/000341078. Epub 2012 Jul 3.


Background: Adult granulosa cell tumors (GCTs) are frequently hormonally active. Thus, hormonal agents have been evaluated for the treatment of advanced-stage or recurrent disease.

Case report: A 39-year-old patient presented with recurrent GCT. The patient received multiple treatment modalities, including surgery and 2 different chemotherapy regimens (cisplatin- and taxanebased). Abdominal computed tomography following these treatments showed local recurrence with multiple implants. The patient's inhibin B level increased to 187 pg/ml at this time. The patient was treated with leuprolide 11.25 mg every 3 months and tamoxifen 20 mg twice daily. The patient's inhibin B level began to decrease after 1 month and returned to normal after 4 months. The patient has been maintained on this treatment for 2 years and has tolerated the drugs well.

Conclusion: The combination of leuprolide and tamoxifen had limited side effects in the presented patient and might be a viable treatment option for women with advanced-stage or recurrent adult ovarian GCTs.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
  • Female
  • Granulosa Cell Tumor / drug therapy*
  • Granulosa Cell Tumor / pathology*
  • Humans
  • Leuprolide / administration & dosage
  • Ovarian Neoplasms / drug therapy*
  • Ovarian Neoplasms / pathology*
  • Tamoxifen / administration & dosage
  • Treatment Outcome


  • Tamoxifen
  • Leuprolide