Juvenile recurrent respiratory papilloma: variable intersurgical intervals

Laryngoscope. 2012 Dec;122(12):2844-9. doi: 10.1002/lary.23534. Epub 2012 Jul 30.


Objectives/hypothesis: To analyze the patterns of surgical frequency in pediatric patients undergoing surgery with CO(2) laser ablation for juvenile onset recurrent respiratory papillomatosis (JORRP). The hypothesis is that over time there is a high variability in surgical frequency independent of the use of an adjuvant therapy.

Study design: Retrospective case review.

Methods: All pediatric patients treated surgically with the CO(2) laser for JORRP by two senior surgeons at a tertiary pediatric hospital over an 11-year period were evaluated. Regression analysis was performed. An online survey was conducted of the American Academy of Pediatric Otolaryngology membership on their practice patterns regarding JORRP.

Results: Twenty-nine patients were identified, and of those, 20 were included in regression analysis. Several distinct patterns were noted. Only five of the 20 patients (25%) had a constant rate of procedures throughout the observation period. Three (15%) of the patients had continual decrease and one (5%) of the patients had a continual increase in the surgical rate throughout the study period. Eleven (55%) had a fluctuation in the pattern of their recurrences. When queried on how they approach when to repeat intervention for JORRP patients, more than 16 responses were given, and the most common determinants included standard set interval, previous operative findings, and previous interval.

Conclusions: The natural fluctuation in intersurgical intervals without the use of any adjuvant therapy confounds the use of intersurgical interval as an outcome measure for the success of adjuvant therapy. Accelerations and decelerations were noted but cannot be explained.

Publication types

  • Comparative Study

MeSH terms

  • Child
  • Child, Preschool
  • Female
  • Humans
  • Incidence
  • Infant
  • Laser Therapy / methods*
  • Laser Therapy / statistics & numerical data
  • Lasers, Gas / therapeutic use*
  • Male
  • Papillomavirus Infections / epidemiology
  • Papillomavirus Infections / surgery*
  • Prognosis
  • Reoperation / statistics & numerical data*
  • Respiratory Tract Infections / epidemiology
  • Respiratory Tract Infections / surgery*
  • Retrospective Studies
  • United States / epidemiology

Supplementary concepts

  • Recurrent respiratory papillomatosis