Impact of oxidative stress in fetal programming

J Pregnancy. 2012;2012:582748. doi: 10.1155/2012/582748. Epub 2012 Jul 11.

Abstract

Intrauterine stress induces increased risk of adult disease through fetal programming mechanisms. Oxidative stress can be generated by several conditions, such as, prenatal hypoxia, maternal under- and overnutrition, and excessive glucocorticoid exposure. The role of oxidant molecules as signaling factors in fetal programming via epigenetic mechanisms is discussed. By linking oxidative stress with dysregulation of specific target genes, we may be able to develop therapeutic strategies that protect against organ dysfunction in the programmed offspring.

Publication types

  • Review

MeSH terms

  • Biomarkers / metabolism
  • Epigenesis, Genetic / physiology*
  • Female
  • Fetal Development / genetics
  • Fetal Development / physiology*
  • Fetal Hypoxia / metabolism
  • Fetal Hypoxia / physiopathology
  • Humans
  • Oxidative Stress / genetics
  • Oxidative Stress / physiology*
  • Pregnancy
  • Prenatal Exposure Delayed Effects / etiology*
  • Prenatal Exposure Delayed Effects / genetics
  • Prenatal Exposure Delayed Effects / metabolism
  • Prenatal Exposure Delayed Effects / physiopathology
  • Prenatal Nutritional Physiological Phenomena
  • Reactive Oxygen Species / metabolism

Substances

  • Biomarkers
  • Reactive Oxygen Species