Postmenopausal skin and estrogen

Gynecol Endocrinol. 2012 Oct:28 Suppl 2:2-6. doi: 10.3109/09513590.2012.705392. Epub 2012 Aug 1.


The aging global population continues to drive increasing demand for cosmaceuticals and cosmetic surgery among older men and women. Since the discovery in the 1990s that estrogen receptors are present in skin cells and decline in number from the onset of menopause in women, researchers have explored a number of ways in which estrogen can improve skin condition. Skin is estrogen responsive, and several studies now exist to support the antiaging properties of estrogen replacement therapies in postmenopausal women. Both systemic and topical estrogens appear to have positive effects on hormonal aging, increasing skin collagen content, thickness, elasticity and hydration. Estrogen therapies may also improve wound healing and reduce the incidence of wound complications. This review explores the potential for targeted estrogen replacement as a therapeutic option for long-term skin management in postmenopausal women.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cosmetic Techniques / adverse effects
  • Dermatologic Surgical Procedures / adverse effects
  • Estrogen Replacement Therapy*
  • Female
  • Humans
  • Postmenopause*
  • Skin / drug effects
  • Skin / injuries
  • Skin / metabolism
  • Skin Aging / drug effects*
  • Wound Healing / drug effects