Determination of in vitro lung solubility and intake-to-dose conversion factor for tritiated lanthanum nickel aluminum alloy

Health Phys. 2012 Sep;103(3):249-54. doi: 10.1097/HP.0b013e318250c60d.


A sample of tritiated lanthanum nickel aluminum alloy (LaNi4.25Al0.75 or LANA.75) similar to that used at the Savannah River Site Tritium Facilities was analyzed to estimate the particle size distribution of this metal tritide powder and the rate at which this material dissolves in the human respiratory tract after it is inhaled. This information is used to calculate the committed effective dose received by a worker after inhaling the material. These doses, which were calculated using the same methodology given in the U.S. Department of Energy Tritium Handbook, are presented as inhalation intake-to-dose conversion factors (DCF). The DCF for this metal tritide was determined to be 9.4 × 10 Sv Bq, which is less than the DCF for tritiated water. Therefore, the radiation worker bioassay programs designed for tritiated water are adequate to monitor for intakes of this material.

MeSH terms

  • Alloys / chemistry*
  • Aluminum / chemistry
  • Humans
  • Inhalation*
  • Lanthanum / chemistry
  • Lung / chemistry*
  • Lung / physiology*
  • Lung / radiation effects
  • Nickel / chemistry
  • Occupational Exposure / adverse effects
  • Occupational Exposure / analysis*
  • Particle Size
  • Radiation Dosage*
  • Solubility
  • Tritium / adverse effects
  • Tritium / chemistry*


  • Alloys
  • Tritium
  • Lanthanum
  • Nickel
  • Aluminum