Cancer prevention by targeting angiogenesis

Nat Rev Clin Oncol. 2012 Sep;9(9):498-509. doi: 10.1038/nrclinonc.2012.120. Epub 2012 Jul 31.

Abstract

Healthy individuals can harbour microscopic tumours and dysplastic foci in different organs in an undetectable and asymptomatic state for many years. These lesions do not progress in the absence of angiogenesis or inflammation. Targeting both processes before clinical manifestation can prevent tumour growth and progression. Angioprevention is a chemoprevention approach that interrupts the formation of new blood vessels when tumour cell foci are in an indolent state. Many efficacious chemopreventive drugs function by preventing angiogenesis in the tumour microenvironment. Blocking the vascularization of incipient tumours should maintain a dormancy state such that neoplasia or cancer exist without disease. The current limitations of antiangiogenic cancer therapy may well be related to the use of antiangiogenic agents too late in the disease course. In this Review, we suggest mechanisms and strategies for using antiangiogenesis agents in a safe, preventive clinical angioprevention setting, proposing different levels of clinical angioprevention according to risk, and indicate potential drugs to be employed at these levels. Finally, angioprevention may go well beyond cancer in the prevention of a range of chronic disorders where angiogenesis is crucial, including different forms of inflammatory or autoimmune diseases, ocular disorders, and neurodegeneration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiogenesis Inhibitors / therapeutic use*
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Antineoplastic Agents / therapeutic use
  • Apoptosis
  • Aspirin / therapeutic use
  • Autophagy
  • Cellular Senescence
  • Chemoprevention / methods*
  • Disease Progression
  • Fenretinide / therapeutic use
  • Humans
  • Hypoglycemic Agents / therapeutic use
  • Inflammation / prevention & control
  • Metformin / therapeutic use
  • Neoplasms / prevention & control*
  • Polyphenols / therapeutic use

Substances

  • Angiogenesis Inhibitors
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antineoplastic Agents
  • Hypoglycemic Agents
  • Polyphenols
  • Fenretinide
  • Metformin
  • Aspirin