Probabilities of orders in linkage calculations

Ann Hum Genet. 1990 Oct;54(4):339-63. doi: 10.1111/j.1469-1809.1990.tb00389.x.

Abstract

The present state of linkage estimation procedures is surveyed. When information on linkage between several loci on one chromosome is given in the form of lod scores or likelihoods, a method is developed for finding the probabilities of the different possible orders of the loci, and the distribution of the map distances between them. This depends largely on a Monte Carlo method of integrating the probabilities.

MeSH terms

  • Female
  • Genetic Linkage*
  • Genotype
  • Humans
  • Lod Score
  • Male
  • Monte Carlo Method