Magainin analogs effective against pathogenic protozoa

Antimicrob Agents Chemother. 1990 Sep;34(9):1824-6. doi: 10.1128/aac.34.9.1824.

Abstract

The in vitro activities of magainin analogs against Blastocystis hominis, Entamoeba histolytica, and Trypanosoma cruzi were assessed by protozoan morphological integrity and motility. The antiprotozoan activities in descending order were magainin B greater than G greater than H, the same order as the alpha-helix contents of the analogs. Magainin B and G were effective against B. hominis, T. cruzi, and E. histolytica.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antimicrobial Cationic Peptides*
  • Antiprotozoal Agents / pharmacology*
  • Cell Membrane / drug effects
  • Entamoeba histolytica / drug effects*
  • Eukaryota / drug effects*
  • Eukaryota / ultrastructure
  • Molecular Sequence Data
  • Peptides / pharmacology*
  • Time Factors
  • Trypanosoma cruzi / drug effects*

Substances

  • Antimicrobial Cationic Peptides
  • Antiprotozoal Agents
  • Peptides
  • magainin B
  • magainin G
  • magainin H