[Isolation and properties of insect-specific neurotoxins from venoms of the spider Lactodectus mactans tredecimguttatus]

Bioorg Khim. 1990 Aug;16(8):1138-40.
[Article in Russian]

Abstract

A method has been developed for isolating five insect-specific neurotoxins and alpha-latrotoxin from venom of the Latrodectus mactans tredecimguttatus spider by means of ion exchange chromatography on Mono Q and Mono S columns and chromatography on hydroxylapatite column. LD 50 of all the toxins are determined.

Publication types

  • English Abstract
  • Letter

MeSH terms

  • Animals
  • Black Widow Spider
  • Chromatography, Ion Exchange
  • Mice
  • Mice, Inbred BALB C
  • Nervous System / drug effects*
  • Spider Venoms / chemistry
  • Spider Venoms / isolation & purification*
  • Spider Venoms / toxicity

Substances

  • Spider Venoms
  • alpha-latrotoxin