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Review
. 2012 Aug;24(4):460-6.
doi: 10.1016/j.ceb.2012.05.010. Epub 2012 Jul 30.

Finding the Will and the Way of ERAD Substrate Retrotranslocation

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Review

Finding the Will and the Way of ERAD Substrate Retrotranslocation

Randolph Y Hampton et al. Curr Opin Cell Biol. .

Abstract

ER-associated degradation (ERAD) is a mechanism by which numerous ER-localized proteins are targeted for cytosolic degradation by the ubiquitin-proteasome system. A surprising and still-cryptic requirement of this process is the energy dependent retrotranslocation of both lumenal and membrane-embedded ER proteins into the cytosol for ongoing ubiquitination and proteasomal destruction. The current understanding, results, and open questions are discussed below for this intriguing and critical process of ERAD.

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