Nimodipine can diminish oxidative stress in patients with severe head trauma

J Neurosurg Sci. 2012 Sep;56(3):247-53.

Abstract

Aim: Antioxidative effect of nimodipine was investigated in patient with severe head trauma.

Methods: The patients in group A were treated according to the standard procedures without nimodipine. Other patients in group B were treated with standard procedures plus intravenous nimodipine for a week. Three times per day, blood samples were taken from internal jugular venous saturation probe and central venous catheter for a week. The levels of malondialdehyde (MDA), reduced glutathione (GSH), nitrite, and nitrate, ascorbic acid, retinol and β-carotene in the serum were measured.

Results: MDA levels in group B were significantly lower than those in the group A (P<0.05). As for GSH levels, it was observed that there was a significant increase in GSH levels in group B when compared to those in group A (P<0.01). Comparison of nitrate and nitrite levels in the serum of patient groups showed that these parameters were significantly higher in group B than those in group A (P<0.01). It was seen that there were a significant increase in ascorbic acid (P<0.01) and β-carotene (P<0.05) levels in group B when compared to those in group A. Values of retinol levels were slightly higher in group B than that of group A, and there was no significant difference between the groups.

Conclusion: Severe head trauma may increase oxidative stress. Administration of nimodipine may prevent the oxidative stress and may augment endogenous antioxidative defense systems in patients with severe head trauma.

MeSH terms

  • Adolescent
  • Adult
  • Antioxidants / metabolism
  • Ascorbic Acid / blood
  • Calcium Channel Blockers / administration & dosage
  • Child
  • Craniocerebral Trauma / drug therapy*
  • Craniocerebral Trauma / metabolism*
  • Female
  • Glutathione / blood
  • Humans
  • Injections, Intravenous
  • Lipid Peroxidation / drug effects*
  • Male
  • Malondialdehyde / blood
  • Middle Aged
  • Nimodipine / administration & dosage*
  • Nitrates / blood
  • Nitrites / blood
  • Oxidative Stress / drug effects*
  • Trauma Severity Indices
  • Vitamin A / blood
  • Young Adult
  • beta Carotene / blood

Substances

  • Antioxidants
  • Calcium Channel Blockers
  • Nitrates
  • Nitrites
  • beta Carotene
  • Vitamin A
  • Malondialdehyde
  • Nimodipine
  • Glutathione
  • Ascorbic Acid