Better prognosis of multiple sclerosis in patients who experienced a full-term pregnancy

Eur Neurol. 2012;68(3):150-5. doi: 10.1159/000338847. Epub 2012 Jul 31.


Objective: We conducted a longitudinal prospective study to evaluate the long-term effect of pregnancy on the progression of multiple sclerosis (MS).

Method: Parous female MS patients were extracted from the database of Isfahan multiple sclerosis society (IMSS). Through comparing the annual relapsing rate during a mean of 4 years before pregnancy versus a mean of 6 years after delivery, MS progression influenced by the pregnancy was analyzed.

Result: 102 female patients were included in our study. The mean annual relapsing rate 4 years prior to pregnancy was significantly higher than at the subsequent 6 years after delivery (1.06 vs. 0.45, p < 0.001). In addition, the annual relapsing rate in years prior to pregnancy was significantly higher than each trimester of gestation (p < 0.001). Furthermore, there was a 2.2-fold increased risk of having a relapse in individuals who had experienced more relapses prior to pregnancy, and a 0.8-fold decreased in the risk of having more relapses with older age at the onset of MS.

Conclusion: Although the course of MS was deteriorated 3 months after delivery, it was not statistically significant comparing annual relapsing rates during the years prior to pregnancy. Moreover, the rate of disease progression slowed down in the 6-year period monitored after delivery.

MeSH terms

  • Adult
  • Databases, Factual / statistics & numerical data
  • Disability Evaluation
  • Disease Progression
  • Female
  • Humans
  • Multiple Sclerosis / diagnosis*
  • Predictive Value of Tests
  • Pregnancy
  • Pregnancy Complications*
  • Prognosis
  • Recurrence
  • Retrospective Studies
  • Young Adult