Classifying collective cancer cell invasion

Nat Cell Biol. 2012 Aug;14(8):777-83. doi: 10.1038/ncb2548.


Most invasive solid tumours display predominantly collective invasion, in which groups of cells invade the peritumoral stroma while maintaining cell-cell contacts. As the concepts and experimental models for functional analysis of collective cancer cell invasion are rapidly developing, we propose a framework for addressing potential mechanisms, experimental strategies and technical challenges to study this process.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carcinoma / pathology
  • Carcinoma / physiopathology*
  • Humans
  • Neoplasm Invasiveness*
  • Neoplasms / pathology
  • Neoplasms / physiopathology*