Regulation of dendritic branching by Cdc42 GAPs

Genes Dev. 2012 Aug 1;26(15):1653-8. doi: 10.1101/gad.199034.112.


Nerve cells form elaborate, highly branched dendritic trees that are optimized for the receipt of synaptic signals. Recent work published in this issue of Genes & Development by Rosario and colleagues (pp. 1743-1757) shows that a Cdc42-specific GTPase-activating protein (NOMA-GAP) regulates the branching of dendrites by neurons in the top layers of the mouse cortex. The results raise interesting questions regarding the specification of arbors in different cortical layers and the mechanisms of dendrite branching.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Actin Depolymerizing Factors / metabolism*
  • Animals
  • Dendrites / metabolism*
  • Female
  • GTPase-Activating Proteins / metabolism*
  • Neocortex / growth & development*
  • Neocortex / metabolism*
  • cdc42 GTP-Binding Protein / metabolism*


  • Actin Depolymerizing Factors
  • GTPase-Activating Proteins
  • TCGAP protein, mouse
  • cdc42 GTP-Binding Protein