Update on the management of disorders of sex development

Pediatr Clin North Am. 2012 Aug;59(4):853-69. doi: 10.1016/j.pcl.2012.05.020.


A number of factors have contributed to a sharp increase in the number of publications related to disorders of sex development (DSD) in the past 5 years, namely: the establishment of a consensus in 2006 about nomenclature, investigations and the need to treat these patients in a multidisciplinary setting; increase of the knowledge base about genetic mechanisms of normal and abnormal sex development; critical appraisal about the timing and nature of genital surgery in patients with DSD. Herein, the authors present a comprehensive review with up-to-date data about the approach to the newborn with ambiguous genitalia as well as the diagnosis and management of the most common DSD.

Publication types

  • Review

MeSH terms

  • Disorders of Sex Development / classification
  • Disorders of Sex Development / diagnosis
  • Disorders of Sex Development / psychology
  • Disorders of Sex Development / surgery*
  • Female
  • Humans
  • Infant, Newborn
  • Male
  • Physical Examination
  • Pregnancy
  • Prenatal Diagnosis
  • Sex Determination Analysis
  • Urologic Surgical Procedures*