ACS chemical neuroscience molecule spotlight on RG1678

ACS Chem Neurosci. 2011 Dec 21;2(12):685-6. doi: 10.1021/cn200108z.

Abstract

RG1678 is a glycine transporter-1 inhibitor currently in Phase III trials for the treatment of the negative symptoms of schizophrenia and is being developed by Roche (in combination with Chugai). Recent Phase II data shows that RG1678 is effective in reducing the negative symptoms when given in combination with second generation antipsychotics.

Keywords: GlyT1; RG1678; Schizophrenia; glycine transporter-1 inhibitor; negative symptoms.

Publication types

  • Review

MeSH terms

  • Animals
  • Clinical Trials, Phase III as Topic / trends
  • Glycine Plasma Membrane Transport Proteins / antagonists & inhibitors*
  • Glycine Plasma Membrane Transport Proteins / metabolism
  • Humans
  • Neurosciences
  • Piperazines / chemistry*
  • Piperazines / pharmacology*
  • Piperazines / therapeutic use
  • Schizophrenia / drug therapy
  • Schizophrenia / metabolism
  • Societies, Scientific
  • Sulfones / chemistry*
  • Sulfones / pharmacology*
  • Sulfones / therapeutic use

Substances

  • (4-(3-fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl)(5-methanesulfonyl-2-(2,2,2-trifluoro-1-methylethoxy)phenyl)methanone
  • Glycine Plasma Membrane Transport Proteins
  • Piperazines
  • SLC6A9 protein, human
  • Sulfones