Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity

Immunology. 2012 Sep;137(1):1-19. doi: 10.1111/j.1365-2567.2012.03591.x.


More than half of the known protein tyrosine phosphatases (PTPs) in the human genome are expressed in T cells, and significant progress has been made in elucidating the biology of these enzymes in T-cell development and function. Here we provide a systematic review of the current understanding of the roles of PTPs in T-cell activation, providing insight into their mechanisms of action and regulation in T-cell receptor signalling, the phenotypes of their genetically modified mice, and their possible involvement in T-cell-mediated autoimmune disease. Our projection is that the interest in PTPs as mediators of T-cell homeostasis will continue to rise with further functional analysis of these proteins, and PTPs will be increasingly considered as targets of immunomodulatory therapies.

Publication types

  • Research Support, N.I.H., Extramural
  • Review
  • Systematic Review

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology
  • Autoimmunity*
  • Cell Communication
  • Homeostasis
  • Humans
  • Lymphocyte Activation
  • Mice
  • Protein Tyrosine Phosphatases / immunology
  • Protein Tyrosine Phosphatases / metabolism*
  • Receptors, Antigen, T-Cell / immunology
  • Receptors, Antigen, T-Cell / metabolism*
  • Signal Transduction
  • T-Lymphocytes / enzymology
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / metabolism*


  • Receptors, Antigen, T-Cell
  • Protein Tyrosine Phosphatases