Generating an iPSC bank for HLA-matched tissue transplantation based on known donor and recipient HLA types

Cell Stem Cell. 2012 Aug 3;11(2):147-52. doi: 10.1016/j.stem.2012.07.014.


The likelihood for immunological rejection of Human Leukocyte Antigens (HLA)-mismatched induced pluripotent stem cells (iPSCs) limits their therapeutic potential. Here we show how a tissue bank from 150 selected homozygous HLA-typed volunteers could match 93% of the UK population with a minimal requirement for immunosuppression. Our model provides a practical approach for using existing HLA-typed samples to generate an iPSC stem cell bank that circumvents prospective typing of a large number of individuals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • HLA Antigens / immunology*
  • Histocompatibility Testing*
  • Humans
  • Induced Pluripotent Stem Cells / cytology*
  • Induced Pluripotent Stem Cells / immunology*
  • Stem Cell Transplantation / methods*
  • Tissue Donors*
  • Transplantation, Homologous


  • HLA Antigens