Serum neurofilament concentrations in children with prolonged febrile seizures

J Neurol Sci. 2012 Oct 15;321(1-2):39-42. doi: 10.1016/j.jns.2012.07.043. Epub 2012 Aug 3.


Objective: Neurofilament (NF) is a major cytoskeletal protein of neurons. Elevation of serum NF concentration suggests neuronal injury, especially damage to axons. We assessed neuronal damage in febrile seizure (FS) by using NF.

Methods: We used enzyme-linked immunosorbent assay to measure serum levels of the phosphorylated form of NF-heavy chain (pNF-H) in 42 children with FS and 28 controls.

Results: Serum pNF-H levels in children with prolonged febrile seizure (PFS) (n=29) were significantly higher than those in the controls (p<0.001). There were no significant differences in serum pNF-H levels between children with simple febrile seizure (n=9) and the controls. There was a significant correlation between seizure duration and serum pNF-H levels during the first week in children with FS (p=0.022, r=0.37).

Conclusion: Our results suggest that PFS could lead to some degree of neuronal damage even in the absence of abnormal clinical neurological findings during the short-term follow up period.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Child, Preschool
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Infant
  • Male
  • Neurofilament Proteins / blood*
  • Seizures, Febrile / blood*


  • Neurofilament Proteins
  • neurofilament protein H