A pH-responsive fluorescent probe and photosensitiser based on a self-quenched phthalocyanine dimer

Mei-Rong Ke; Dennis K P Ng; Pui-Chi Lo

doi:10.1039/c2cc34327d

A pH-responsive fluorescent probe and photosensitiser based on a self-quenched phthalocyanine dimer

Chem Commun (Camb). 2012 Sep 18;48(72):9065-7. doi: 10.1039/c2cc34327d. Epub 2012 Aug 3.

Authors

Mei-Rong Ke¹, Dennis K P Ng, Pui-Chi Lo

Affiliation

¹ Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.

PMID: 22864462
DOI: 10.1039/c2cc34327d

Abstract

A self-quenched zinc(II) phthalocyanine dimer linked with an acid-sensitive ketal unit has been prepared, which can be activated in an acidic environment (pH = 5.0-6.5) as a result of the cleavage of the ketal linker and separation of the phthalocyanine units, resulting in enhanced fluorescence emission and singlet oxygen production.

MeSH terms

Dimerization*
Fluorescent Dyes / chemistry*
Fluorescent Dyes / pharmacology*
HT29 Cells
Humans
Hydrogen-Ion Concentration
Indoles / chemistry*
Indoles / pharmacology*
Intracellular Space / drug effects
Isoindoles
Photosensitizing Agents / chemistry*
Photosensitizing Agents / pharmacology*

Substances

Fluorescent Dyes
Indoles
Isoindoles
Photosensitizing Agents
phthalocyanine