Nephrogenic systemic fibrosis and gadolinium-based contrast media: updated ESUR Contrast Medium Safety Committee guidelines

Eur Radiol. 2013 Feb;23(2):307-18. doi: 10.1007/s00330-012-2597-9. Epub 2012 Aug 4.


Purpose: To update the guidelines of the Contrast Media Safety Committee (CMSC) of the European Society of Urogenital Radiology (ESUR) on nephrogenic systemic fibrosis and gadolinium-based contrast media.

Areas covered: Topics reviewed include the history, clinical features and prevalence of nephrogenic systemic fibrosis and the current understanding of its pathophysiology. The risk factors for NSF are discussed and prophylactic measures are recommended. The stability of the different gadolinium-based contrast media and the potential long-term effects of gadolinium in the body have also been reviewed.

Publication types

  • Review

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Child
  • Contrast Media / adverse effects*
  • Contrast Media / pharmacology
  • Dose-Response Relationship, Drug
  • Europe
  • Female
  • Gadolinium / adverse effects*
  • Gadolinium / pharmacology
  • Humans
  • Incidence
  • Infant, Newborn
  • Male
  • Nephrogenic Fibrosing Dermopathy / chemically induced*
  • Nephrogenic Fibrosing Dermopathy / epidemiology
  • Nephrogenic Fibrosing Dermopathy / pathology
  • Patient Safety
  • Practice Guidelines as Topic / standards*
  • Radiographic Image Enhancement
  • Radiology / standards
  • Risk Assessment
  • Societies, Medical


  • Contrast Media
  • Gadolinium