Antihypoxic and antioxidant effects of exogenous succinic acid and aminothiol succinate-containing antihypoxants

Bull Exp Biol Med. 2012 Jul;153(3):336-9. doi: 10.1007/s10517-012-1709-5.

Abstract

Pronounced antihypoxic and antioxidant effects of preventive injection of succinic acid, aminothiol antihypoxants gutimine and amtizol, and succinate-containing aminothiol antihypoxants gutimine succinate and amtizol succinate to Wistar rats with acute hypoxic hypoxia have been demonstrated. Exogenous succinic acid was inferior to aminothiol compounds by antihypoxic effect, but superior to them by its effect on the level of LPO products. Succinate in the aminothiol molecule modulated the intensity of their antihypoxic and antioxidant effects. It did not modulate the antihypoxic activity of amtizol, but reduced the antihypoxic effect of gutimine, presumably because of the physicochemical characteristics of aminothiols. Comparison of the intensities of antihypoxic and antioxidant effects of the studied drugs showed no direct relationship between these effects.

MeSH terms

  • Animals
  • Antioxidants / chemistry
  • Antioxidants / therapeutic use*
  • Guanylthiourea / chemistry
  • Guanylthiourea / therapeutic use
  • Hypoxia / drug therapy*
  • Lipid Peroxidation / drug effects
  • Male
  • Rats
  • Rats, Wistar
  • Succinic Acid / chemistry
  • Succinic Acid / therapeutic use*
  • Thiadiazoles / chemistry
  • Thiadiazoles / therapeutic use

Substances

  • Antioxidants
  • Thiadiazoles
  • amtizol
  • Succinic Acid
  • Guanylthiourea