Bax and Bak are required for apogossypolone, a BH3-mimetic, induced apoptosis in chronic lymphocytic leukemia cells

Leuk Lymphoma. 2013 May;54(5):1097-100. doi: 10.3109/10428194.2012.718344. Epub 2012 Sep 4.
No abstract available

Publication types

  • Letter

MeSH terms

  • Animals
  • Apoptosis / drug effects*
  • Apoptosis / genetics*
  • Gene Expression
  • Gene Knockout Techniques
  • Gossypol / analogs & derivatives*
  • Gossypol / pharmacology
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
  • Mice
  • bcl-2 Homologous Antagonist-Killer Protein / genetics*
  • bcl-2-Associated X Protein / genetics*

Substances

  • apogossypolone
  • bcl-2 Homologous Antagonist-Killer Protein
  • bcl-2-Associated X Protein
  • Gossypol