Structure elucidation and inhibitory effects on NO production of clerodane diterpenes from Ajuga decumbens

Planta Med. 2012 Sep;78(14):1579-93. doi: 10.1055/s-0032-1315215. Epub 2012 Aug 7.

Abstract

Three new clerodane diterpenes (1-3), together with five known analogues (4-8), have been isolated from the whole plants of Ajuga decumbens. Their structures were established by detailed spectroscopic and spectrometric data analyses (IR, ESIMS, HR-ESIMS, 1D and 2D NMR). The inhibitory activities of these diterpenes on LPS-induced NO production were evaluated, and compounds 1-4 and 6-8 showed inhibitory effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ajuga / chemistry*
  • Animals
  • Cell Line
  • Diterpenes, Clerodane / chemistry*
  • Diterpenes, Clerodane / isolation & purification
  • Diterpenes, Clerodane / pharmacology
  • Medicine, Chinese Traditional
  • Mice
  • Molecular Structure
  • Nitric Oxide / metabolism*
  • Plant Extracts / chemistry*
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Polysaccharides / adverse effects

Substances

  • Diterpenes, Clerodane
  • Plant Extracts
  • Polysaccharides
  • Nitric Oxide