The paper presents the results of treatment in 22 obese persons with hypoenergetical nutrition of 4200 kJ with the simultaneous application of dexfenfluoramine in the daily dose of 30 mg in the course of three months. During this period of time an average weight loss of 7.5 kg was achieved, and a loss of 10 kg and more in one third of the patients. The controlled laboratory parameters did not show any significant deviations, and side effects in the form of mouth dryness and diarrhea were rare, and of a lighter intensity so that they did not demand the stop of therapy. When correctly indicated, dexfenfluoramine presents a valuable supplement in the therapeutic arsenal for obesity treatment, because thanks to its anorexigenic effect it eases the conducting of hypoenergetical nutrition and improves the treatment effect of this pathological condition.