MR imaging in a patient with Leigh's disease (subacute necrotizing encephalomyelopathy)

Pediatr Radiol. 1990;21(1):62-3. doi: 10.1007/BF02010818.


Leigh's disease, also known as subacute necrotizing encephalomyelopathy, is a rare progressive neurological disorder of childhood that was first described by Leigh in 1951. Diagnosis of this disease can be difficult because onset is usually insidious and can present with a number of different focal findings, however diagnostic imaging has been shown to be of benefit in this regard. We present a patient with Leigh's disease in whom serial MR imaging studies helped to make the diagnosis and also demonstrated the dynamic characteristic of this disease process.

Publication types

  • Case Reports

MeSH terms

  • Brain / pathology*
  • Brain Edema / pathology
  • Female
  • Humans
  • Infant
  • Leigh Disease / pathology*
  • Magnetic Resonance Imaging*
  • Necrosis