Effect of Traumeel S on pain and discomfort in radiation-induced oral mucositis: a preliminary observational study

Altern Ther Health Med. Jul-Aug 2012;18(4):12-8.

Abstract

Context: Painful oral mucositis is an almost inevitable side effect of radiotherapy of head and neck tumors that simultaneous chemotherapy intensifies and that is notoriously difficult to treat. In a previous study, chemotherapy-induced stomatitis in children undergoing bone marrow transplantation responded well to the homeopathic complex remedy Traumeel S.

Objective: To evaluate the efficacy of Traumeel S in the management of radiation-induced oral mucositis in patients with head and neck tumors.

Design: The research team designed a nonrandomized, prospective, observational study with matched pairs.

Setting: The research team performed the study in a tertiary cancer-care center at the Institute of Radiotherapy and Special Oncology, Medical School Hanover, Germany.

Participants: The participants were 20 patients who were receiving radiotherapy or radiochemotherapy for head and neck tumors.

Intervention: Five times per day during the observational period, participants self-administered daily mouth rinses with either sage tea (Salvia officinalis, control group) or Traumeel S solution (intervention group).

Outcome measures: Two independent physicians determined the grade of oral mucositis at least once per week, and the research team derived the degree of oral pain from diaries that participants kept.

Results: Both groups were comparable in terms of tumor and treatment characteristics. The research team could not confirm any appreciable specific effect of Traumeel S on the primary endpoints; the limited reduction in pain for the intervention group compared to the control group was not significant, and the more frequent analgesia in the Traumeel S group most likely explained that reduction. Among the secondary endpoints, loss of taste and swallowing difficulty responded to Traumeel S to some extent.

Conclusions: Traumeel S may have some potential in the treatment of radiation-induced oral mucositis, but its possible effects need confirmation by further studies. This article discusses some methodological requirements.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Oral
  • Aged
  • Analgesics / administration & dosage*
  • Dose-Response Relationship, Drug
  • Facial Pain / drug therapy
  • Facial Pain / etiology
  • Female
  • Germany
  • Head and Neck Neoplasms / radiotherapy
  • Humans
  • Male
  • Middle Aged
  • Minerals / administration & dosage*
  • Mouth Mucosa / drug effects
  • Mucositis / complications*
  • Plant Extracts / administration & dosage*
  • Prospective Studies
  • Radiation Injuries / complications*
  • Treatment Outcome

Substances

  • Analgesics
  • Minerals
  • Plant Extracts
  • Traumeel S