Kidney injury molecule-1 as a promising biomarker for acute kidney injury in premature babies

Am J Perinatol. 2013 Mar;30(3):245-52. doi: 10.1055/s-0032-1323587. Epub 2012 Aug 8.

Abstract

Objective: To evaluate the role of urinary kidney injury molecule-1 (uKIM-1) in early determination of renal injury in premature infants with respiratory distress syndrome (RDS).

Study design: Forty-eight premature babies hospitalized in the neonatal intensive care unit were included in the study and divided into three groups: group I, healthy premature infants; group II, preterm infants with RDS without acute kidney injury (AKI); group III, preterm infants with RDS and AKI. uKIM-1 and creatinine along with serum creatinine levels were measured with enzyme-linked immunosorbent assay on days 1, 3, and 7 of life.

Results: On day 1, uKIM-1 levels in babies with RDS and AKI were higher than the other two groups. In this group, a significant increase in uKIM-1 levels were detected on day 3 (p = 0.015). The sensitivity and specificity of uKIM-1 were calculated as 73.3% and 76.9%, respectively, along with the increase of 0.5 ng per milligram of creatinine of uKIM-1 in day 3, when compared with values on day 1. Elevated uKIM-1 on day 7 was found to increase the risk of death by 7.3 times.

Conclusion: Serial uKIM-1 measurements can be used as a noninvasive indicator of kidney injury and uKIM-1 can be an ideal biomarker in premature infants.

Publication types

  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Kidney Injury / diagnosis*
  • Acute Kidney Injury / etiology
  • Acute Kidney Injury / urine
  • Area Under Curve
  • Biomarkers / urine
  • Case-Control Studies
  • Creatinine / blood
  • Creatinine / urine
  • Female
  • Hepatitis A Virus Cellular Receptor 1
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Infant, Premature, Diseases / diagnosis*
  • Infant, Premature, Diseases / urine
  • Male
  • Membrane Glycoproteins / urine*
  • ROC Curve
  • Receptors, Virus
  • Respiratory Distress Syndrome, Newborn / complications
  • Statistics, Nonparametric

Substances

  • Biomarkers
  • HAVCR1 protein, human
  • Hepatitis A Virus Cellular Receptor 1
  • Membrane Glycoproteins
  • Receptors, Virus
  • Creatinine

Supplementary concepts

  • Respiratory Distress Syndrome In Premature Infants