Symptomatic Trichomonas vaginalis infection in the setting of severe nitroimidazole allergy: successful treatment with boric acid

Sex Health. 2012 Sep;9(4):389-91. doi: 10.1071/SH11114.


This report describes a patient with symptomatic Trichomonas vaginalis infection who was unable to tolerate nitroimidazole drugs because of severe hypersensitivity, for which desensitisation was not possible. Use of intravaginal clotrimazole, intravaginal paromomycin, intravaginal furazolidone, povidone-iodine douches, and oral nitazoxanide were unsuccessful in eradicating the patient's T. vaginalis infection. A 2-month course of intravaginal topical boric acid subsequently achieved a complete symptomatic cure and the patient remained T. vaginalis wet prep- and culture-negative 60 days after treatment.

Publication types

  • Case Reports

MeSH terms

  • Administration, Intravaginal
  • Adult
  • Boric Acids / administration & dosage
  • Boric Acids / therapeutic use*
  • Drug Hypersensitivity
  • Female
  • Humans
  • Nitroimidazoles / immunology
  • Trichomonas Vaginitis / drug therapy*
  • Trichomonas vaginalis*


  • Boric Acids
  • Nitroimidazoles
  • boric acid