Urinary leukotriene E4 as a biomarker of exposure, susceptibility and risk in asthma

Immunol Allergy Clin North Am. 2012 Aug;32(3):433-45. doi: 10.1016/j.iac.2012.06.012.

Abstract

Measurement of urinary leukotriene E(4) (uLTE(4)) is a sensitive and noninvasive method of assaying total body cysteinyl leukotriene production and changes in cysteinyl leukotriene production. Recent studies have reported on novel uLTE(4) receptor interactions, and new applications for uLTE(4), as a biomarker of environmental exposure to tobacco smoke and ambient air pollution, a predictor of risk for asthma exacerbations related to tobacco smoke, and a marker of susceptibility to leukotriene receptor antagonists.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Anti-Asthmatic Agents / therapeutic use
  • Asthma / diagnosis*
  • Asthma / drug therapy
  • Asthma / epidemiology
  • Biomarkers
  • Disease Susceptibility
  • Environmental Exposure
  • Humans
  • Leukotriene E4 / urine*
  • Risk

Substances

  • Adrenal Cortex Hormones
  • Anti-Asthmatic Agents
  • Biomarkers
  • Leukotriene E4