The PRRT2 mutation c.649dupC is the so far most frequent cause of benign familial infantile convulsions

Seizure. 2012 Nov;21(9):740-2. doi: 10.1016/j.seizure.2012.07.006. Epub 2012 Aug 9.


Purpose: Mutations in the PRRT2 gene have been recently described as a cause of paroxysmal kinesigenic dyskinesia, infantile convulsions with choreoathetosis syndrome and, less often, infantile convulsions. We have analysed the frequency of PRRT2 mutations in families with benign familial infantile convulsions without paroxysmal kinesigenic dyskinesia.

Methods and results: Direct sequencing of the coding region identified the PRRT2 mutation c.649dupC in 5/5 families with infantile convulsions. The mutation was present in 23 family members, of which 18 were clinically affected and 2 were obligate carriers. The affected carriers of this mutation presented with different types of epileptic seizures during early childhood but did not develop additional neurological symptoms later in life.

Conclusion: Our data demonstrate that the PRRT2 mutation c.649dupC is a frequent cause of benign familial infantile convulsions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Child, Preschool
  • Dyskinesias / diagnosis
  • Epilepsy, Benign Neonatal / diagnosis*
  • Epilepsy, Benign Neonatal / genetics*
  • Female
  • Humans
  • Infant
  • Male
  • Membrane Proteins / genetics*
  • Middle Aged
  • Mutation / genetics*
  • Nerve Tissue Proteins / genetics*
  • Pedigree
  • Young Adult


  • Membrane Proteins
  • Nerve Tissue Proteins
  • PRRT2 protein, human